Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal

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Parra, Esteban J, Mazurek, Andrew, Gignoux, Christopher R, Sockell, Alexandra, Agostino, Michael, Morris, Andrew P, Petty, Lauren E, Hanis, Craig L, Cox, Nancy J, Valladares-Salgado, Adan et al (show 2 more authors) , Below, Jennifer E and Cruz, Miguel (2017) Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal. PLOS ONE, 12 (2). e0172880-.

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Official URL: http://dx.doi.org/10.1371/journal.pone.0172880

Abstract

We carried out an admixture mapping study of lipid traits in two samples from Mexico City. Native American locus ancestry was significantly associated with triglyceride levels in a broad region of chromosome 11 overlapping the BUD13, ZNF259 and APOA5 genes. In our fine-mapping analysis of this region using dense genome-wide data, rs964184 is the only marker included in the 99% credible set of SNPs, providing strong support for rs964184 as the causal variant within this region. The frequency of the allele associated with increased triglyceride concentrations (rs964184-G) is between 30-40% higher in Native American populations from Mexico than in European populations. The evidence currently available for this variant indicates that it may be exerting its effect through three potential mechanisms: 1) modification of enhancer activity, 2) regulation of the expression of several genes in cis and/or trans, or 3) modification of the methylation patterns of the promoter of the APOA5 gene.

Item Type:	Article
Uncontrolled Keywords:	Humans, Genetic Predisposition to Disease, Triglycerides, Carrier Proteins, Membrane Transport Proteins, RNA-Binding Proteins, Gene Frequency, Haplotypes, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Alleles, Adult, Middle Aged, Mexican Americans, Female, Male, Genome-Wide Association Study, Apolipoprotein A-V, White People
Depositing User:	Symplectic Admin
Date Deposited:	10 Apr 2017 06:31
Last Modified:	12 Oct 2023 17:53
DOI:	10.1371/journal.pone.0172880
Open Access URL:	http://journals.plos.org/plosone/article?id=10.137...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3006901