Bronchoalveolar Lavage Proteomics in Patients with Suspected Lung Cancer


Carvalho, Ana Sofia, Cuco, Celia Marina, Lavareda, Carla, Miguel, Francisco, Ventura, Mafalda, Almeida, Sonia, Pinto, Paula, de Abreu, Tiago Tavares, Rodrigues, Luis Vaz, Seixas, Susana et al (show 7 more authors) (2017) Bronchoalveolar Lavage Proteomics in Patients with Suspected Lung Cancer. SCIENTIFIC REPORTS, 7 (1). 42190-.

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Abstract

Lung cancer configures as one of the deadliest types of cancer. The future implementation of early screening methods such as exhaled breath condensate analysis and low dose computed tomography (CT) as an alternative to current chest imaging based screening will lead to an increased burden on bronchoscopy units. New approaches for improvement of diagnosis in bronchoscopy units, regarding patient management, are likely to have clinical impact in the future. Diagnostic approaches to address mortality of lung cancer include improved early detection and stratification of the cancers according to its prognosis and further response to drug treatment. In this study, we performed a detailed mass spectrometry based proteome analysis of acellular bronchoalveolar lavage (BAL) fluid samples on an observational prospective cohort consisting of 90 suspected lung cancer cases which were followed during two years. The thirteen new lung cancer cases diagnosed during the follow up time period clustered, based on liquid chromatography-mass spectrometry (LC-MS) data, with lung cancer cases at the time of BAL collection. Hundred and thirty-tree potential biomarkers were identified showing significantly differential expression when comparing lung cancer versus non-lung cancer. The regulated biomarkers showed a large overlap with biomarkers detected in tissue samples.

Item Type: Article
Uncontrolled Keywords: Bronchoalveolar Lavage Fluid, Humans, Adenocarcinoma, Carcinoma, Squamous Cell, Lung Neoplasms, Proteome, Early Diagnosis, Chromatography, Liquid, Cluster Analysis, Risk Factors, Prospective Studies, Bronchoalveolar Lavage, Smoking, Proteomics, Principal Component Analysis, Aged, Aged, 80 and over, Middle Aged, Female, Male, Mass Spectrometry, Biomarkers, Tumor, Adenocarcinoma of Lung
Depositing User: Symplectic Admin
Date Deposited: 13 Apr 2017 06:47
Last Modified: 19 Jan 2023 07:06
DOI: 10.1038/srep42190
Open Access URL: https://www.nature.com/articles/srep42190
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URI: https://livrepository.liverpool.ac.uk/id/eprint/3006965
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