Cardiac re-entry dynamics & self-termination in DT-MRI based model of Human Foetal Heart



Biktasheva, IV ORCID: 0000-0003-2906-2881, Anderson, RA, Holden, AV, Pervolaraki, E and Wen, F
(2019) Cardiac re-entry dynamics & self-termination in DT-MRI based model of Human Foetal Heart. Frontiers in Physics.

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Abstract

The effect of heart geometry and anisotropy on cardiac re-entry dynamics and self-termination is studied here in anatomically realistic computer simulations of human foetal heart. 20 weeks of gestational age human foetal heart isotropic and anisotropic anatomy models from diffusion tensor MRI data sets are used in the computer simulations. The fibre orientation angles of the heart were obtained from the DT-MRI primary eigenvalues. In a spatially homogeneous electrophysiological mono domain model with the DT-MRI based heart geometries, we initiate simplified Fitz-Hugh-Nagumo kinetics cardiac re-entry at a prescribed location in a 2D slice, and in the full 3D anatomy model. In a slice of the heart, the MRI based fibre anisotropy changes the re-entry dynamics from pinned to anatomical re-entry. In the full 3D MRI based model, the foetal heart fibre anisotropy changes the re-entry dynamics from a persistent re-entry to the re-entry self-termination.

Item Type: Article
Additional Information: submitted to Chaos: An Interdisciplinary Journal of Nonlinear Science, Focus Issue on the topic of Complex Cardiac Dynamics
Uncontrolled Keywords: q-bio.TO, q-bio.TO
Depositing User: Symplectic Admin
Date Deposited: 24 Apr 2017 10:42
Last Modified: 03 Sep 2019 07:10
Open Access URL: https://doi.org/10.3389/fphy.2018.00015
Related URLs:
URI: http://livrepository.liverpool.ac.uk/id/eprint/3007030
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