Steptoe, Paul J ORCID: 0000-0002-7323-1681, Scott, Janet T ORCID: 0000-0001-8030-5223, Baxter, Julia M, Parkes, Craig K, Dwivedi, Rahul, Czanner, Gabriela, Vandy, Matthew J, Momorie, Fayiah, Fornah, Alimamy D, Komba, Patrick et al (show 4 more authors)
(2017)
Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016.
EMERGING INFECTIOUS DISEASES, 23 (7).
pp. 1102-1109.
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Abstract
We conducted a case-control study in Freetown, Sierra Leone, to investigate ocular signs in Ebola virus disease (EVD) survivors. A total of 82 EVD survivors with ocular symptoms and 105 controls from asymptomatic civilian and military personnel and symptomatic eye clinic attendees underwent ophthalmic examination, including widefield retinal imaging. Snellen visual acuity was <6/7.5 in 75.6% (97.5% CI 63%-85.7%) of EVD survivors and 75.5% (97.5% CI 59.1%-87.9%) of controls. Unilateral white cataracts were present in 7.4% (97.5% CI 2.4%-16.7%) of EVD survivors and no controls. Aqueous humor from 2 EVD survivors with cataract but no anterior chamber inflammation were PCR-negative for Zaire Ebola virus, permitting cataract surgery. A novel retinal lesion following the anatomic distribution of the optic nerve axons occurred in 14.6% (97.5% CI 7.1%-25.6%) of EVD survivors and no controls, suggesting neuronal transmission as a route of ocular entry.
Item Type: | Article |
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Uncontrolled Keywords: | Humans, Hemorrhagic Fever, Ebola, Retinal Diseases, Severity of Illness Index, Population Surveillance, Prevalence, Case-Control Studies, Ophthalmoscopes, Visual Acuity, History, 21st Century, Adult, Survivors, Sierra Leone, Female, Male, Ebolavirus, Young Adult |
Depositing User: | Symplectic Admin |
Date Deposited: | 15 May 2017 06:15 |
Last Modified: | 19 Jan 2023 07:04 |
DOI: | 10.3201/eid2307.161608 |
Open Access URL: | https://wwwnc.cdc.gov/eid/article/23/7/16-1608_art... |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3007451 |
Available Versions of this Item
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A Novel Retinal Finding in Ebola Survivors, A Case-Control Study. (deposited 07 Apr 2017 14:10)
- Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016. (deposited 15 May 2017 06:15) [Currently Displayed]