Adverse drug reactions in hospitalised children

Thiesen, S (2016) Adverse drug reactions in hospitalised children. PhD thesis, University of Liverpool.

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Abstract

Adverse Drug Reactions (ADRs) are a global health problem and a leading cause of death, illness and injury in economically developed countries. Therapeutic response, as well the occurrence of undesired effects, can differ significantly between children and adults and many drugs have not been sufficiently studied in the paediatric population. Existing studies on ADRs in children differ widely in study design and outcome reporting, and many are methodically problematic. The incidence and characteristics of ADRs in hospitalised children and factors associated with an increased risk of experiencing and ADR, were assessed in a large, prospective, observational study. 17.7% of all children experienced at least one ADR. Opiate analgesia and drugs used in general anaesthesia (GA) accounted for more than 50% of all drugs implicated in ADRs. Less than 1% of ADRs caused permanent harm or required admission to a higher level of care. Children post GA were more than six times more likely to experience an ADR than children who had not received a GA (HR 6.38; 95%CI 5.3-7.7). Other risk factors identified were increasing age (HR 1.05 for each year; 95%CI 1.04-1.07), increasing number of medicines (HR 1.25 for each additional ... (continues)

Item Type:	Thesis (PhD)
Uncontrolled Keywords:	Adverse Drug Reactions, Cisplatin, Pharmacogenetics, Ototoxicity, Hospitalised Children, Children
Divisions:	Faculty of Health and Life Sciences > Faculty of Health and Life Sciences
Depositing User:	Symplectic Admin
Date Deposited:	22 Aug 2017 06:16
Last Modified:	07 Feb 2025 13:18
DOI:	10.17638/03008116
Supervisors:	Turner, M ORCID: 0000-0002-5299-8656 Pirmohamed, M ORCID: 0000-0002-7534-7266 Smyth, R
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3008116