A prospective advanced magnetic resonance imaging study of newly diagnosed epilepsy

Alonazi, BK (2017) A prospective advanced magnetic resonance imaging study of newly diagnosed epilepsy PhD thesis, University of Liverpool.

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Abstract

According to the World Health Organization (WHO), approximately 50 million people in the world have active epilepsy. Epilepsy is the most common neurological disorder after migraine, stroke and Alzheimer’s disease. Epilepsy disorder affects men and women of all ages, races and social classes. There is an extensive neuroimaging literature describing patients with chronic epilepsy. However, few studies have investigated brain structural changes in patients with newly diagnosed epilepsy (NDE) using quantitative magnetic resonance imaging (MRI). The main goal of this thesis was to determine the nature and extent of brain structural and functional differences in patients with NDE using different MRI techniques compared with healthy controls. The first study was to determine the morphometric changes in patients with NDE compared to healthy controls using quantitative MRI analysis. The second study was to identify functional connectivity differences (in the whole brain and regions of interest) in patients with NDE and healthy controls using resting state functional magnetic resonance imaging (RS-fMRI). All study participants were recruited from the Walton Centre NHS Foundation Trust, Liverpool. All had been diagnosed ... (continues)

Item Type:	Thesis (PhD)
Divisions:	Faculty of Health & Life Sciences
Depositing User:	Symplectic Admin
Date Deposited:	08 Sep 2017 09:16
Last Modified:	06 Feb 2025 07:30
DOI:	10.17638/03008153
Supervisors:	Keller, S ORCID: 0000-0001-5247-9795 Marson, A ORCID: 0000-0002-6861-8806 Sluming, V
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3008153
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