Biomedical diagnostics enabled by integrated organic and printed electronics

Ahmadraji, T, Gonzalez-Macia, L, Ritvonen, T, Willert, A, Tuurala, S, Donaghy, D, Suhonen, M, Smart, D, Efremov, V, Morrin, A
et al (show 4 more authors) (2017) Biomedical diagnostics enabled by integrated organic and printed electronics. Analytical Chemistry, 89 (14). pp. 7447-7454.

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Organic and printed electronics integration has the potential to revolutionize many technologies, including biomedical diagnostics. This work demonstrates the successful integration of multiple printed electronic functionalities into a single device capable of the measurement of hydrogen peroxide and total cholesterol. The single-use device employed printed electrochemical sensors for hydrogen peroxide electroreduction integrated with printed electrochromic display and battery. The system was driven by a conventional electronic circuit designed to illustrate the complete integration of silicon integrated circuits via pick and place or using organic electronic circuits. The device was capable of measuring 8 μL samples of both hydrogen peroxide (0–5 mM, 2.72 × 10–6 A·mM–1) and total cholesterol in serum from 0 to 9 mM (1.34 × 10–8 A·mM–1, r2 = 0.99, RSD < 10%, n = 3), and the result was output on a semiquantitative linear bar display. The device could operate for 10 min via a printed battery, and display the result for many hours or days. A mobile phone “app” was also capable of reading the test result and transmitting this to a remote health care provider. Such a technology could allow improved management of conditions such as hypercholesterolemia.

Item Type: Article
Uncontrolled Keywords: Humans, Hydrogen Peroxide, Cholesterol, Electrodes, Electronics, Biomedical Technology, Printing, Electric Power Supplies, Electrochemical Techniques
Depositing User: Symplectic Admin
Date Deposited: 03 Jul 2017 13:36
Last Modified: 19 Jan 2023 07:00
DOI: 10.1021/acs.analchem.7b01012
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