The molecular pathophysiology of chronic non-bacterial osteomyelitis (CNO)-a systematic review.



Hofmann, Sigrun Ruth, Kapplusch, Franz, Mäbert, Katrin and Hedrich, Christian Michael ORCID: 0000-0002-1295-6179
(2017) The molecular pathophysiology of chronic non-bacterial osteomyelitis (CNO)-a systematic review. Molecular and cellular pediatrics, 4 (1). 7 - ?.

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Abstract

Chronic non-bacterial osteomyelitis (CNO) belongs to the growing spectrum of autoinflammatory diseases and primarily affects the skeletal system. Peak onset ranges between 7 and 12 years of age. The clinical spectrum of CNO covers sometimes asymptomatic inflammation of single bones at the one end and chronically active or recurrent multifocal osteitis at the other.Despite the intense scientific efforts, the exact molecular mechanisms of CNO remain unknown. Recent data suggest CNO as a genetically complex disorder with dysregulated TLR4/MAPK/inflammasome signaling cascades resulting in an imbalance between pro- and anti-inflammatory cytokine expression, leading to osteoclast activation and osteolytic lesions.In this manuscript, the current understanding of molecular patho-mechanisms in CNO will be discussed.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 06 Sep 2017 08:54
Last Modified: 27 Sep 2021 20:10
DOI: 10.1186/s40348-017-0073-y
URI: https://livrepository.liverpool.ac.uk/id/eprint/3008435