Chemical Composition and In Vitro Cytotoxic and Antimicrobial Activities of the Essential Oil from Leaves of Zanthoxylum monogynum St. Hill (Rutaceae).



Silva, Fernanda B da, Santos, Nara O Dos, Pascon, Renata C, Vallim, Marcelo A ORCID: 0000-0002-6929-0566, Figueiredo, Carlos R ORCID: 0000-0003-3680-4070, Martins, Roberto C Campos and Sartorelli, Patricia
(2017) Chemical Composition and In Vitro Cytotoxic and Antimicrobial Activities of the Essential Oil from Leaves of Zanthoxylum monogynum St. Hill (Rutaceae). Medicines (Basel, Switzerland), 4 (2). E31-.

[img] Text
med-04-2017.pdf - Published version

Download (338kB)

Abstract

<b>Background</b>: The <i>Zanthoxylum monogynum</i> species belongs to the family Rutaceae and is found in Southeast, Midwest, and Northeast Brazil. For this genus several biological activities have been described. <b>Methods</b>: The essential oil (EO) was obtained from the leaves of <i>Zanthoxylum monogynum</i> by hydro-distillation and was analyzed by gas chromatograph and gas chromatograph/mass spectrometry (GC and GC/MS). Also the EO of <i>Z. monogynum</i> was evaluated for in vitro cytotoxic activity against six tumor cell lines and for antimicrobial activity, performing disk diffusion and MIC assays with yeast and bacterial strains. <b>Results</b>: The chemical analysis afforded the identification of 18 components (99.0% of the EO). The major components were found to be citronellol (43.0%) and farnesol (32.0%). The <i>in vitro</i> cytotoxic activity against tumor cell lines, resulted in IC<sub>50</sub> values ranging from 11-65 µg/mL against all tested cell lines. Antimicrobial activity of the essential oil was also tested and oil was effective, especially against Cryptococcus sp. yeast. All the tested yeast strains showed at least 90% growth inhibition. <b>Conclusions</b>: the essential oil from leaves of <i>Z. monogynum</i> has a different qualitative and quantitative composition when compared to the composition previously described. Also this EO has significant cytotoxic activity and moderate activity against <i>Cryptococcus</i> sp. and <i>Saccharomyces cereviseae</i> yeasts.

Item Type: Article
Uncontrolled Keywords: Rutaceae, Zanthoxylum monogynum, antimicrobial activity, cytotoxic activity, essential oil
Depositing User: Symplectic Admin
Date Deposited: 28 Jul 2017 14:00
Last Modified: 13 Feb 2024 15:09
DOI: 10.3390/medicines4020031
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3008682