Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis

Collapse authors list.
Treutlein, Jens, Frank, Josef, Streit, Fabian, Reinbold, Celine S, Juraeva, Dilafruz, Degenhardt, Franziska, Rietschel, Liz, Witt, Stephanie H, Forstner, Andreas J, Ridinger, Monika et al (show 32 more authors) , Strohmaier, Jana, Wodarz, Norbert, Dukal, Helene, Foo, Jerome C, Hoffmann, Per, Herms, Stefan, Heilmann-Heimbach, Stefanie, Soyka, Michael, Maier, Wolfgang, Gaebel, Wolfgang, Dahmen, Norbert, Scherbaum, Norbert, Mueller-Myhsok, Bertram ORCID: 0000-0002-0719-101X, Lucae, Susanne, Ising, Marcus, Stickel, Felix, Berg, Thomas, Roggenbuck, Ulla, Joeckel, Karl-Heinz, Scholz, Henrike, Zimmermann, Ulrich S, Buch, Stephan, Sommer, Wolfgang H, Spanagel, Rainer, Brors, Benedikt, Cichon, Sven, Mann, Karl, Kiefer, Falk, Hampe, Jochen, Rosendahl, Jonas, Noethen, Markus M and Rietschel, Marcella (2017) Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. GENES, 8 (7). E183-.

Text genes-08-00183.pdf - Published version Download (277kB)

Abstract

The present study investigated the genetic contribution to alcohol dependence (AD) using genome-wide association data from three German samples. These comprised patients with: (i) AD; (ii) chronic alcoholic pancreatitis (ACP); and (iii) alcohol-related liver cirrhosis (ALC). Single marker, gene-based, and pathway analyses were conducted. A significant association was detected for the <i>ADH1B</i> locus in a gene-based approach (<i>p</i>_uncorrected = 1.2 × 10^-6; <i>p</i>_corrected = 0.020). This was driven by the AD subsample. No association with <i>ADH1B</i> was found in the combined ACP + ALC sample. On first inspection, this seems surprising, since <i>ADH1B</i> is a robustly replicated risk gene for AD and may therefore be expected to be associated also with subgroups of AD patients. The negative finding in the ACP + ALC sample, however, may reflect genetic stratification as well as random fluctuation of allele frequencies in the cases and controls, demonstrating the importance of large samples in which the phenotype is well assessed.

Item Type:	Article
Uncontrolled Keywords:	alcohol dependence, chronic alcoholic pancreatitis, alcoholic liver cirrhosis, genome-wide association study, alcohol dehydrogenase, ADH1B, ADH1C
Depositing User:	Symplectic Admin
Date Deposited:	02 Aug 2017 07:46
Last Modified:	13 Feb 2024 14:58
DOI:	10.3390/genes8070183
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3008767