Brain, Kate, Carter, Ben, Lifford, Kate J, Burke, Olivia, Devaraj, Anand, Baldwin, David R, Duffy, Stephen and Field, John K ORCID: 0000-0003-3951-6365
(2017)
Impact of low-dose CT screening on smoking cessation among high-risk participants in the UK Lung Cancer Screening Trial.
THORAX, 72 (10).
pp. 912-918.
Abstract
Background Smoking cessation was examined among high-risk participants in the UK Lung Cancer Screening (UKLS) Pilot Trial of low-dose CT screening. Methods High-risk individuals aged 50–75 years who completed baseline questionnaires were randomised to CT screening (intervention) or usual care (no screening control). Smoking habit was determined at baseline using self-report. Smokers were asked whether they had quit smoking since joining UKLS at T1 (2 weeks after baseline scan results or control assignment) and T2 (up to 2 years after recruitment). Intention-to-treat (ITT) regression analyses were undertaken, adjusting for baseline lung cancer distress, trial site and sociodemographic variables. Results Of a total 4055 individuals randomised to CT screening or control, 1546 were baseline smokers (759 intervention, 787 control). Smoking cessation rates were 8% (control n=36/479) versus 14% (intervention n=75/527) at T1 and 21% (control n=79/377) versus 24% (intervention n=115/488) at T2. ITT analyses indicated that the odds of quitting among screened participants were significantly higher at T1 (adjusted OR (aOR) 2.38, 95% CI 1.56 to 3.64, p<0.001) and T2 (aOR 1.60, 95% CI 1.17 to 2.18, p=0.003) compared with control. Intervention participants who needed additional clinical investigation were more likely to quit in the longer term compared with the control group (aOR 2.29, 95% CI 1.62 to 3.22, p=0.007) and those receiving a negative result (aOR 2.43, 95% CI 1.54 to 3.84, p<0.001). Conclusions CT lung cancer screening for high-risk participants presents a teachable moment for smoking cessation, especially among those who receive a positive scan result. Further behavioural research is needed to evaluate optimal strategies for integrating smoking cessation intervention with stratified lung cancer screening.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | Humans, Lung Neoplasms, Tomography, X-Ray Computed, Mass Screening, Pilot Projects, Radiation Dosage, Smoking Cessation, Aged, Middle Aged, England, Female, Male, Early Detection of Cancer, Surveys and Questionnaires |
Depositing User: | Symplectic Admin |
Date Deposited: | 02 Aug 2017 13:20 |
Last Modified: | 19 Jan 2023 06:58 |
DOI: | 10.1136/thoraxjnl-2016-209690 |
Open Access URL: | https://www.ncbi.nlm.nih.gov/pubmed/28710339 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3008783 |