Epigenetics in SLE

Hedrich, Christian Michael ORCID: 0000-0002-1295-6179 (2017) Epigenetics in SLE. CURRENT RHEUMATOLOGY REPORTS, 19 (9). 58-.

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Abstract

<h4>Purpose of review</h4>Systemic lupus erythematosus is a severe autoimmune/inflammatory condition of unknown pathophysiology. Though genetic predisposition is essential for disease expression, risk alleles in single genes are usually insufficient to confer disease. Epigenetic dysregulation has been suggested as the missing link between genetic risk and the development of clinically evident disease.<h4>Recent findings</h4>Over the past decade, epigenetic events moved into the focus of research targeting the molecular pathophysiology of SLE. Epigenetic alteration can be the net result of preceding infections, medication, diet, and/or other environmental influences. While altered DNA methylation and histone modifications had already been established as pathomechanisms, DNA hydroxymethylation was more recently identified as an activating epigenetic mark. Defective epigenetic control contributes to uncontrolled cytokine and co-receptor expression, resulting in immune activation and tissue damage in SLE. Epigenetic alterations promise potential as disease biomarkers and/or future therapeutic targets in SLE and other autoimmune/inflammatory conditions.

Item Type:	Article
Uncontrolled Keywords:	Lupus, Epigenetic, Inflammation, Methylation, Hydroxymethylation, Histone, Non-coding RNA
Depositing User:	Symplectic Admin
Date Deposited:	09 Aug 2017 09:26
Last Modified:	19 Jan 2023 06:58
DOI:	10.1007/s11926-017-0685-1
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3008885