MicroRNA Profiling in Cartilage Ageing

Balaskas, Panagiotis, Goljanek-Whysall, Katarzyna ORCID: 0000-0001-8166-8800, Clegg, Peter, Fang, Yongxiang, Cremers, Andy, Emans, Pieter, Welting, Tim and Peffers, Mandy ORCID: 0000-0001-6979-0440 (2017) MicroRNA Profiling in Cartilage Ageing INTERNATIONAL JOURNAL OF GENOMICS, 2017 (1). 2713725-. ISSN 2314-436X, 2314-4378

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Abstract

Osteoarthritis (OA) is the most common age-related joint disorder in man. MicroRNAs (miRNA), a class of small noncoding RNAs, are potential therapeutic targets for regulating molecular mechanisms in both disease and ageing. Whilst there is an increasing amount of research on the roles of miRNAs in ageing, there has been scant research on age-related changes in miRNA in a cartilage. We undertook a microarray study on young and old human cartilages. Findings were validated in an independent cohort. Contrasts between these samples identified twenty differentially expressed miRNAs in a cartilage from old donors, derived from an OA environment which clustered based on OA severity. We identified a number of recognised and novel miRNAs changing in cartilage ageing and OA including miR-126: a potential new candidate with a role in OA pathogenesis. These analyses represent important candidates that have the potential as cartilage ageing and OA biomarkers and therapeutic targets.

Item Type:	Article
Uncontrolled Keywords:	31 Biological Sciences, 3105 Genetics, Biotechnology, Osteoarthritis, Aging, Arthritis, Genetics, 2.1 Biological and endogenous factors, Musculoskeletal
Depositing User:	Symplectic Admin
Date Deposited:	08 Sep 2017 07:43
Last Modified:	10 Sep 2026 23:55
DOI:	10.1155/2017/2713725
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3009333
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