Raj, A
(2016)
Assessment of the function of the central macula in diabetic maculopathy.
Doctor of Medicine thesis, University of Liverpool.
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Abstract
Introduction: Neural degeneration of the retina has been demonstrated in diabetes mellitus (DM). Several studies have focused on retinal neural function in diabetic retinopathy (DR) but few have assessed function in diabetic maculopathy, the leading cause of visual disturbance in DM. Aim: To correlate, cross-sectionally and longitudinally, central macular function to diabetic maculopathy. Methods: Treatment-naïve subjects with DM were recruited to three groups: i) diabetic controls (no visible signs of DR); ii) early maculopathy (maculopathy not meeting criteria for clinically significant macular oedema (CSMO)); and iii) sight-threatening maculopathy (presence of CSMO and/or ischaemic maculopathy). A group of healthy controls was also recruited. Subjects underwent assessment of best correct visual acuity (BCVA), contrast sensitivity (CS), optical coherence tomography (OCT), microperimetry (MP), multifocal electroretinography (mfERG), oscillatory potential (OP) and systemic risk factors (HbA1c, serum cholesterol and blood pressure). Subjects with DM were invited to follow-up at 6 months and 12 months where assessments were repeated. One-way ANOVA and ANCOVA were used for cross-sectional and longitudinal analysis, ... (continues)
| Item Type: | Thesis (Doctor of Medicine) |
|---|---|
| Divisions: | Faculty of Health and Life Sciences > Faculty of Health and Life Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 18 Dec 2017 10:54 |
| Last Modified: | 05 Nov 2024 20:02 |
| DOI: | 10.17638/03009729 |
| Supervisors: |
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| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3009729 |
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