<i>Onchocerca volvulus</i>: The Road from Basic Biology to a Vaccine

Lustigman, Sara, Makepeace, Benjamin L ORCID: 0000-0002-6100-6727, Klei, Thomas R, Babayan, Simon A, Hotez, Peter, Abraham, David and Bottazzi, Maria Elena
(2018) <i>Onchocerca volvulus</i>: The Road from Basic Biology to a Vaccine. TRENDS IN PARASITOLOGY, 34 (1). pp. 64-79.

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Human onchocerciasis - commonly known as river blindness - is one of the most devastating yet neglected tropical diseases, leaving many millions in sub-Saharan Africa blind and/or with chronic disabilities. Attempts to eliminate onchocerciasis, primarily through the mass drug administration of ivermectin, remains challenging and has been heightened by the recent news that drug-resistant parasites are developing in some populations after years of drug treatment. Needed, and needed now, in the fight to eliminate onchocerciasis are new tools, such as preventive and therapeutic vaccines. This review summarizes the progress made to advance the onchocerciasis vaccine from the research laboratory into the clinic.

Item Type: Article
Uncontrolled Keywords: Animals, Humans, Onchocerca volvulus, Onchocerciasis, Ocular, Vaccines, Antiparasitic Agents, Drug Resistance
Depositing User: Symplectic Admin
Date Deposited: 02 Oct 2017 11:21
Last Modified: 13 Oct 2023 16:05
DOI: 10.1016/j.pt.2017.08.011
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3009733