Spatio-temporal models to determine association between Campylobacter cases and environment



Sanderson, RA, Maas, JA, Blain, AP, Gorton, R, Ward, J, O'Brien, SJ ORCID: 0000-0003-2896-8999, Hunter, PR and Rushton, SP
(2018) Spatio-temporal models to determine association between Campylobacter cases and environment. International Journal of Epidemiology, 47 (1). 202 - 216.

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Abstract

Background Campylobacteriosis is a major cause of gastroenteritis in the UK, and although 70% of cases are associated with food sources, the remainder are probably associated with wider environmental exposure. Methods In order to investigate wider environmental transmission, we conducted a spatio-temporal analysis of the association of human cases of Campylobacter in the Tyne catchment with weather, climate, hydrology and land use. A hydrological model was used to predict surface-water flow in the Tyne catchment over 5 years. We analysed associations between population-adjusted Campylobacter case rate and environmental factors hypothesized to be important in disease using a two-stage modelling framework. First, we investigated associations between temporal variation in case rate in relation to surface-water flow, temperature, evapotranspiration and rainfall, using linear mixed-effects models. Second, we used the random effects for the first model to quantify how spatial variation in static landscape features of soil and land use impacted on the likely differences between subcatchment associations of case rate with the temporal variables. Results Population-adjusted Campylobacter case rates were associated with periods of high predicted surface-water flow, and during above average temperatures. Subcatchments with cattle on stagnogley soils, and to a lesser extent sheep plus cattle grazing, had higher Campylobacter case rates. Conclusions Areas of stagnogley soils with mixed livestock grazing may be more vulnerable to both Campylobacter spread and exposure during periods of high rainfall, with resultant increased risk of human cases of the disease.

Item Type: Article
Uncontrolled Keywords: Campylobacterr, hydrology, livestock, rainfall, soils
Depositing User: Symplectic Admin
Date Deposited: 03 Oct 2017 15:49
Last Modified: 20 May 2021 07:26
DOI: 10.1093/ije/dyx217
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3009753