Formation of hydrophobic drug nanoparticles via ambient solvent evaporation facilitated by branched diblock copolymers

Wais, Ulrike, Jackson, Alexander W, He, Tao and Zhang, Haifei ORCID: 0000-0001-5142-5824 (2017) Formation of hydrophobic drug nanoparticles via ambient solvent evaporation facilitated by branched diblock copolymers. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 533 (1). pp. 245-253.

Text Drug Nanoparticles by Ambient Solvent Evaporation_revised.docx - Author Accepted Manuscript Download (1MB)

Abstract

Hydrophobic drug nanoparticles have been prepared by ambient solvent evaporation from ethanol at room temperature. Poly(ethylene glycol)-b-(N-isopropylacrylamide) (PEG-b-PNIPAm) branched diblock copolymers are employed to prevent drug crystallization during solvent evaporation and to stabilize the drug nanoparticles once suspended in aqueous media. After the initial solvent evaporation the dry materials obtained exhibit excellent stability during storage and can be readily dissolved in water to produce aqueous drug nanoparticles suspensions. Among the hydrophobic compounds investigated, Ketoprofen nanoparticles (D_h≈200nm, stable up to 9 months in solution) can be produced with a drug suspension yield of 96% at a drug:polymer ratio of 0.33:1 or a drug suspension yield of 80% at a drug:polymer ratio of 1:1. UV-vis spectroscopy has been used to determine the yield of drug suspended in aqueous media while cryo-TEM, dynamic light scattering (DLS) and powder x-ray diffraction (PXRD) are used to characterize the drug nanoparticles prepared.

Item Type:	Article
Uncontrolled Keywords:	Poorly water-soluble drugs, Drug nanoparticles, Branched block copolymers, Solvent evaporation, Ketoprofen
Depositing User:	Symplectic Admin
Date Deposited:	13 Oct 2017 14:26
Last Modified:	19 Jan 2023 06:53
DOI:	10.1016/j.ijpharm.2017.09.067
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3010059