Phylogenetic structure of European <i>Salmonella</i> Enteritidis outbreak correlates with national and international egg distribution network



Dallman, Tim, Inns, Thomas ORCID: 0000-0002-1218-958X, Jombart, Thibaut, Ashton, Philip, Loman, Nicolas, Chatt, Carol, Messelhaeusser, Ute, Rabsch, Wolfgang, Simon, Sandra, Nikisins, Sergejs
et al (show 9 more authors) (2016) Phylogenetic structure of European <i>Salmonella</i> Enteritidis outbreak correlates with national and international egg distribution network. MICROBIAL GENOMICS, 2 (8). e000070-.

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Abstract

Outbreaks of <i>Salmonella</i> Enteritidis have long been associated with contaminated poultry and eggs. In the summer of 2014 a large multi-national outbreak of <i>Salmonella</i> Enteritidis phage type 14b occurred with over 350 cases reported in the United Kingdom, Germany, Austria, France and Luxembourg. Egg supply network investigation and microbiological sampling identified the source to be a Bavarian egg producer. As part of the international investigation into the outbreak, over 400 isolates were sequenced including isolates from cases, implicated UK premises and eggs from the suspected source producer. We were able to show a clear statistical correlation between the topology of the UK egg distribution network and the phylogenetic network of outbreak isolates. This correlation can most plausibly be explained by different parts of the egg distribution network being supplied by eggs solely from independent premises of the Bavarian egg producer (Company X). Microbiological sampling from the source premises, traceback information and information on the interventions carried out at the egg production premises all supported this conclusion. The level of insight into the outbreak epidemiology provided by whole-genome sequencing (WGS) would not have been possible using traditional microbial typing methods.

Item Type: Article
Uncontrolled Keywords: Salmonella, whole-genome sequencing, traceback investigation, foodborne outbreak
Depositing User: Symplectic Admin
Date Deposited: 26 Oct 2017 09:06
Last Modified: 05 Oct 2023 11:34
DOI: 10.1099/mgen.0.000070
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3010901