The human immune response to oral vaccination with live-attenuated Salmonella Typhi (Ty21a)

Pennington, SH
(2017) The human immune response to oral vaccination with live-attenuated Salmonella Typhi (Ty21a). PhD thesis, University of Liverpool.

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Typhoid fever continues to represent a significant threat to global health and currently licensed vaccines confer incomplete protection. In 1975, an oral typhoid vaccine was developed through the chemical mutagenesis of pathogenic Salmonella enterica serovar Typhi strain Ty2. This vaccine, which is designated Ty21a, has been used for many years to combat disease; it is well-tolerated with a cumulative efficacy of approximately 58% up to 2 years following its administration. A great deal of data have been collected concerning peripheral cellular and humoral immune responses to this vaccine; however, only surrogate measures of mucosal immunity exist. The data presented within this thesis demonstrate the value of direct mucosal sampling and provide fresh insight into aspects of human immunity which have not previously been explored. The data presented describe the strength, diversity and duration of mucosal and peripheral cellular immune responses to Ty21a. In addition, the data demonstrate the wider impact of Ty21a on responses to non-related pathogens. Data presented here support the use of direct mucosal sampling to study host-pathogen interaction and the development of S. Typhi based vectors.

Item Type: Thesis (PhD)
Divisions: Faculty of Health and Life Sciences > Faculty of Health and Life Sciences
Depositing User: Symplectic Admin
Date Deposited: 21 Dec 2017 15:34
Last Modified: 15 Apr 2021 07:14
DOI: 10.17638/03011423