Human Ageing Genomic Resources: new and updated databases



Tacutu, Robi, Thornton, Daniel, Johnson, Emily, Budovsky, Arie, Barardo, Diogo, Craig, Thomas ORCID: 0000-0001-7029-310X, Diana, Eugene, Lehmann, Gilad, Toren, Dmitri, Wang, Jingwei
et al (show 2 more authors) (2017) Human Ageing Genomic Resources: new and updated databases. NUCLEIC ACIDS RESEARCH, 46 (D1). D1083 - D1090.

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Abstract

In spite of a growing body of research and data, human ageing remains a poorly understood process. Over 10 years ago we developed the Human Ageing Genomic Resources (HAGR), a collection of databases and tools for studying the biology and genetics of ageing. Here, we present HAGR’s main functionalities, highlighting new additions and improvements. HAGR consists of six core databases: (i) the GenAge database of ageing-related genes, in turn composed of a dataset of >300 human ageing-related genes and a dataset with >2000 genes associated with ageing or longevity in model organisms; (ii) the AnAge database of animal ageing and longevity, featuring >4000 species; (iii) the GenDR database with >200 genes associated with the life-extending effects of dietary restriction; (iv) the LongevityMap database of human genetic association studies of longevity with >500 entries; (v) the DrugAge database with >400 ageing or longevity-associated drugs or compounds; (vi) the CellAge database with >200 genes associated with cell senescence. All our databases are manually curated by experts and regularly updated to ensure a high quality data. Cross-links across our databases and to external resources help researchers locate and integrate relevant information. HAGR is freely available online (http://genomics.senescence.info/).

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 17 Nov 2017 16:33
Last Modified: 25 Jan 2022 19:53
DOI: 10.1093/nar/gkx1042
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3012389