Clinicopathological Features of Ocular Adnexal Mantle-Cell Lymphoma in an International Multicenter Cohort



Knudsen, Marina KH, Rasmussen, Peter K, Coupland, Sarah E ORCID: 0000-0002-1464-2069, Esmaeli, Bita, Finger, Paul T, Graue, Gerardo F, Grossniklaus, Hans E, Khong, Jwu Jin, McKelvie, Penny A, Mulay, Kaustubh
et al (show 6 more authors) (2017) Clinicopathological Features of Ocular Adnexal Mantle-Cell Lymphoma in an International Multicenter Cohort. JAMA OPHTHALMOLOGY, 135 (12). pp. 1367-1374.

[img] Text
jamaophthalmology_Knudsen_2017_oi_170099.pdf - Published version

Download (614kB)

Abstract

<h4>Importance</h4>To our knowledge, the clinical features of ocular adnexal mantle-cell lymphoma (OA-MCL) have not previously been evaluated in a large multicenter cohort.<h4>Objective</h4>To characterize the clinical features of OA-MCL.<h4>Design, setting, and participants</h4>This retrospective multicenter study included patient data collected from January 1, 1980, through December 31, 2015, at 6 eye cancer centers in 4 countries. Medical records of 55 patients with OA-MCL were reviewed; the median length of follow-up was 33 months.<h4>Main outcomes and measures</h4>Overall survival, disease-specific survival, and progression-free survival were the primary end points.<h4>Results</h4>Fifty-five patients were included; ocular adnexal MCL was found to be most common in older individuals (mean age, 70 years) and men (n = 42 of 55; 76%). Patients with OA-MCL frequently presented with disseminated lymphoma (n = 34 of 55; 62%), and were likely to experience stage IVE disease (n = 35 of 55; 64%), with bilateral involvement (n = 27 of 55; 47%), tumor masses (n = 27 of 36; 75%), and involvement of the orbit (n = 32 of 55; 58%). Chemotherapy with or without external beam radiation therapy was the most frequently used treatment. Overall survival rates for the entire cohort were 65% at 3 years (95% CI, 52%-78%) and 34% at 5 years (95% CI, 21%-47%). Disease-specific survival after 5 years was 38% for the entire cohort (95% CI, 25%-51%); the disease-specific survival adjusted by eye cancer center was better in patients who had received rituximab in addition to the chemotherapy regimen (hazard ratio, 3.3; 95% CI, 1.0-14.7; P = .06). The median progression-free survival was 2.3 years (95% CI, 1.8-2.7 years) in patients who experienced recurrence after primary treatment, and 4.1 years (95% CI, 3.9-4.3 years) in patients who presented with a relapse of systemic lymphoma in the ocular adnexal region.<h4>Conclusions and relevance</h4>These results suggest that the distinctive features of OA-MCL are its appearance in older male individuals, advanced stage and bilateral manifestation at the time of diagnosis, and aggressive course. The prognosis of patients with OA-MCL might be improved by addition of rituximab to chemotherapy treatment.

Item Type: Article
Uncontrolled Keywords: Humans, Lymphoma, Mantle-Cell, Orbital Neoplasms, Eye Neoplasms, Conjunctival Neoplasms, Eyelid Neoplasms, Lymphatic Metastasis, Lacrimal Apparatus Diseases, Antineoplastic Combined Chemotherapy Protocols, Neoplasm Staging, Disease-Free Survival, Combined Modality Therapy, Brachytherapy, Survival Rate, Retrospective Studies, Cohort Studies, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male
Depositing User: Symplectic Admin
Date Deposited: 20 Nov 2017 08:59
Last Modified: 19 Jan 2023 06:50
DOI: 10.1001/jamaophthalmol.2017.4810
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3012406