Bacteria-induced Wnt signalling as a mechanism for malignant development in the intestinal epithelium


Meehan, B (2017) Bacteria-induced Wnt signalling as a mechanism for malignant development in the intestinal epithelium PhD thesis, University of Liverpool.

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Abstract

Colorectal cancer (CRC) is one of the most common cancers worldwide with over a million new cases each year, and evidence implicates chronic inflammation as a risk factor for developing CRC. Inflammatory conditions place stresses on bacteria composing the human gut microbiota and alter the composition of the gut microbiota in favour of pathobiont Escherichia coli (E. coli), with resultant expansion of these bacteria increasing their interactions with the gut mucosa. Mucosa-associated E. coli have been found in high numbers within intestinal tissue taken from IBD and CRC patients. Pro-inflammatory cytokines such as cyclooxygenase-2 (COX-2) are commonly implicated in inflammatory disease, and can be released upon tissue damage or following infection. COX-2-driven prostaglandin E2 (PGE2) increases are believed to activate the cancer-related Wnt signalling pathway, with accumulation and subsequent nuclear translocation of the key Wnt protein ß-catenin aiding proliferation, migration and metastasis. With COX-2 implicated in CRC development and progression and a cascade for COX-2 and PGE2 stimulating cancer cell growth via Wnt activation, mucosaassociated E. coli infection could lead to sustained increases in Wnt ... (continues)

Item Type: Thesis (PhD)
Divisions: Faculty of Health & Life Sciences
Depositing User: Symplectic Admin
Date Deposited: 18 Dec 2017 11:30
Last Modified: 31 Oct 2024 07:01
DOI: 10.17638/03012547
Supervisors:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3012547
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