Drug nanoparticles by emulsion-freeze-drying via the employment of branched block copolymer nanoparticles

Wais, Ulrike, Jackson, Alexander W, Zuo, Yanming, Xiang, Yu, He, Tao and Zhang, Haifei ORCID: 0000-0001-5142-5824 (2016) Drug nanoparticles by emulsion-freeze-drying via the employment of branched block copolymer nanoparticles. JOURNAL OF CONTROLLED RELEASE, 222. pp. 141-150.

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Abstract

A large percentage of drug compounds exhibit low water solubility and hence low bioavailability and therapeutic efficacy. This may be addressed by preparation of drug nanoparticles, leading to enhanced dissolution rate and direct use for treatment. Various methods have been developed to produce drug nanocrystals, including wet milling, homogenization, solution precipitation, emulsion diffusion, and the recently developed emulsion freeze-drying. The drawback for these methods may include difficult control in particles size, use of surfactants & polymer, and low ratio of drug to stabilizer. Here, biocompatible branched block copolymer nanoparticles with lightly-crosslinked hydrophobic core and hydrophilic surface groups are synthesized by the direct monomer-to-particle methodology, characterized, and then used as scaffold polymer/surfactant to produce drug nanoparticles via the emulsion-freeze-drying approach. This method can be used for model organic dye and different poorly water-soluble drugs. Aqueous drug nanoparticle dispersions can be obtained with high ratio of drug to stabilizer and relatively uniform nanoparticle sizes.

Item Type:	Article
Uncontrolled Keywords:	Drug nanoparticles, Poorly water-soluble drugs, Block copolymer, Nanoparticles, Emulsion, Freeze drying
Depositing User:	Symplectic Admin
Date Deposited:	21 Nov 2017 14:04
Last Modified:	19 Jan 2023 06:50
DOI:	10.1016/j.jconrel.2015.12.022
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3012635