Hofmann, Sigrun Ruth, Boettger, Fanny, Range, Ursula, Lueck, Christian, Morbach, Henner, Girschick, Hermann Joseph, Suttorp, Meinolf and Hedrich, Christian Michael ORCID: 0000-0002-1295-6179
(2017)
Serum Interleukin-6 and CCL11/Eotaxin May Be Suitable Biomarkers for the Diagnosis of Chronic Nonbacterial Osteomyelitis.
FRONTIERS IN PEDIATRICS, 5.
256-.
Text
fped-05-00256.pdf - Published version Download (990kB) |
Abstract
Objectives: Chronic recurrent multifocal osteomyelitis (CRMO), the most severe form of chronic nonbacterial osteomyelitis (CNO), is an autoinflammatory bone disorder. In the absence of diagnostic criteria or biomarkers, CNO/CRMO remains a diagnosis of exclusion. The aim of this study was to identify biomarkers for diagnosing multifocal disease (CRMO). Study design: Sera from 71 pediatric CRMO patients, 11 patients with osteoarticular infections, 62 patients with juvenile idiopathic arthritis (JIA), 7 patients with para-infectious or reactive arthritis, and 43 patients with acute leukemia or lymphoma, as well as 59 healthy individuals were collected. Multiplex analysis of 18 inflammation- and/or bone remodeling-associated serum proteins was performed. Statistical analysis included univariate ANOVA, discriminant analysis, univariate receiver operating characteristic (ROC) analysis, and logistic regression analyses. Results: For 14 of 18 blood serum proteins, significant differences were determined between CRMO patients, at least one alternative diagnosis, or healthy controls. Multi-component discriminant analysis delivered five biomarkers (IL-6, CCL11/eotaxin, CCL5/RANTES, collagen Iα, sIL-2R) for the diagnosis of CRMO. ROC analysis allowed further reduction to a core set of 2 biomarkers (CCL11/eotaxin, IL-6) that are sufficient to discern between CRMO, healthy controls, and alternative diagnoses. Conclusion: Serum biomarkers CCL11/eotaxin and IL-6 differentiate between patients with CRMO, healthy controls, and alternative diagnoses (leukemia and lymphoma, osteoarticular infections, para-infectious arthritis, and JIA). Easily accessible biomarkers may aid in diagnosing CRMO. Further studies testing biomarkers in larger unrelated cohorts are warranted.
Item Type: | Article |
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Uncontrolled Keywords: | chronic nonbacterial osteomyelitis, chronic recurrent multifocal osteomyelitis, inflammation, biomarker, autoinflammation, diagnosis |
Depositing User: | Symplectic Admin |
Date Deposited: | 18 Dec 2017 08:43 |
Last Modified: | 19 Jan 2023 06:46 |
DOI: | 10.3389/fped.2017.00256 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3014330 |