Deregulation of the folate pathway in respiratory tract cancer : molecular and functional consequences


Al-Humairi, IA (2017) Deregulation of the folate pathway in respiratory tract cancer : molecular and functional consequences. Doctor of Philosophy thesis, University of Liverpool.

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Abstract

Respiratory tract (lung and head and neck) cancers constitute a significant public health burden, contributing greatly to the cancer-related mortality worldwide. Folate is an essential nutrient for genome stability through its role in regulating DNA biosynthesis, repair and methylation processes. The deregulation of specific genes encoding for enzymes in this pathway has been implicated in several types of cancer including respiratory tract cancer and might be critical for cancer cell growth. Certain folate-related genes are targets of very common anticancer drugs and their expression has been associated associated with the relevant chemotherapeutic response. The current study sought to expand the current knowledge on folate pathway deregulation in respiratory tract cancer and shed light on as yet unexplored areas. In particular it aims to: 1) explore the expression profile of the core genes of the folate pathway in lung cancer. 2) investigate the potential of sensitising respiratory tract cancer cells to antifolates using well-known epigenetic drugs. 3) assess the impact of manipulating the activity of previously unexplored folate genes on cancer cell response to antifolates. We evaluated the mRNA expression ... (continues)

Item Type: Thesis (Doctor of Philosophy)
Divisions: Faculty of Health and Life Sciences > Faculty of Health and Life Sciences
Depositing User: Symplectic Admin
Date Deposited: 20 Nov 2018 12:56
Last Modified: 01 Nov 2024 04:21
DOI: 10.17638/03014604
Supervisors:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3014604
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