Consideration of corneal biomechanics in the diagnosis and management of keratoconus: is it important?

Bao, FangJun, Geraghty, Brendan ORCID: 0000-0003-0561-6667, Wang, QinMei and Elsheikh, Ahmed ORCID: 0000-0001-7456-1749 (2016) Consideration of corneal biomechanics in the diagnosis and management of keratoconus: is it important? Eye and Vision, 3 (1). 18-. ISSN 2326-0246, 2326-0254

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Abstract

Keratoconus is a bilateral, non-inflammatory, degenerative corneal disease. The occurrence and development of keratoconus is associated with corneal thinning and conical protrusion, which causes irregular astigmatism. With the disruption of the collagen organization, the cornea loses its shape and function resulting in progressive visual degradation. Currently, corneal topography is the most important tool for the diagnosis of keratoconus, which may lead to false negatives among the patient population in the subclinical phase. However, it is now hypothesised that biomechanical destabilisation of the cornea may take place ahead of the topographic evidence of keratoconus, hence possibly assisting with disease diagnosis and management. This article provides a review of the definition, diagnosis, and management strategies for keratoconus based on corneal biomechanics.

Item Type:	Article
Uncontrolled Keywords:	Keratoconus, In vivo, Corneal biomechanics, Corneal collagen cross-linking
Depositing User:	Symplectic Admin
Date Deposited:	15 Jan 2018 07:41
Last Modified:	23 May 2026 00:10
DOI:	10.1186/s40662-016-0048-4
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3016006
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