DC-SIGN Polymorphisms Associated with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users



Steba, Gaby S, Koekkoek, Sylvie M, Vanhommerig, Joost W, Brinkman, Kees, Kwa, David, Van Der Meer, Jan TM, Prins, Maria, Berkhout, Ben, Tanck, Michael, Paxton, William A ORCID: 0000-0001-5200-0801
et al (show 3 more authors) (2018) DC-SIGN Polymorphisms Associated with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users. The Journal of Infectious Diseases, 217 (3). 353 - 357.

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Abstract

We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with HCV susceptibility. An MSM and an IDU cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN SNPs -139, -871 and -939 correlate with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlate with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels.

Item Type: Article
Uncontrolled Keywords: Hepatitis C virus, Lectin, DC-SIGN, Single nucleotide polymorphism, sexual transmission
Depositing User: Symplectic Admin
Date Deposited: 19 Jan 2018 11:06
Last Modified: 30 Sep 2021 23:10
DOI: 10.1093/infdis/jix587
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3016391