SNOM Imaging of a Crypt-Like Feature in Adenocarcinoma Associated with Barrett's Oesophagus

Craig, Timothy, Smith, Andrew D, Holder, Gareth M, Ingham, James, Smith, Caroline I ORCID: 0000-0001-6878-0697, Varro, Andrea, Pritchard, D Mark ORCID: 0000-0001-7971-3561, Barrett, Steve D ORCID: 0000-0003-2960-3334, Martin, David S, Harrison, Paul
et al (show 7 more authors) (2018) SNOM Imaging of a Crypt-Like Feature in Adenocarcinoma Associated with Barrett's Oesophagus. PHYSICA STATUS SOLIDI B-BASIC SOLID STATE PHYSICS, 255 (4). p. 1700518.

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The development of more accurate and sensitive diagnostic techniques is a key factor in efforts to improve cancer survival rates. The technique of infrared aperture fibre scanning near-field optical microscopy (IR-SNOM), together with radiation from the infrared free-electron laser (IR-FEL) on ALICE at Daresbury Laboratory (UK), has been used to obtain IR images of a crypt-like feature and the surrounding tissue; the tissue was taken from a patient with oesophageal adenocarcinoma and with a history of Barrett's oesophagus. We have shown that the DNA signal is enhanced relative to other contributions in the region of the crypt, and the glycoprotein signal shows a less pronounced increase in the region of the crypt. The Amide II signal is found to be anti-correlated with the DNA and glycoprotein profiles. The absorbance of the Amide II signal is found to differ for three different types of cancer tissue. High-resolution IR images of the crypt reveal additional structure that would not be resolved in diffraction-limited techniques.

Item Type: Article
Uncontrolled Keywords: adenocarcinoma, DNA, infrared radiation, scanning near-field optical microscopy, tissue
Depositing User: Symplectic Admin
Date Deposited: 25 Jan 2018 11:16
Last Modified: 19 Jan 2023 06:42
DOI: 10.1002/pssb.201700518
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