Advanced magnetic resonance imaging and quantitative analysis approaches in patients with refractory focal epilepsy

Kreilkamp, Barbara AK ORCID: 0000-0001-6881-5191 (2017) Advanced magnetic resonance imaging and quantitative analysis approaches in patients with refractory focal epilepsy PhD thesis, University of Liverpool.

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Abstract

Background Epilepsy has a high prevalence of 1%, which makes it the most common serious neurological disorder. The most difficult to treat type of epilepsy is temporal lobe epilepsy (TLE) with its most commonly associated lesion being hippocampal sclerosis (HS). About 30-50% of all patients undergoing resective surgery of epileptogenic tissue continue to have seizures postoperatively. Indication for this type of surgery is only given when lesions are clearly visible on magnetic resonance images (MRI). About 30% of all patients with focal epilepsy do not show an underlying structural lesion upon qualitative neuroradiological MRI assessment (MRI-negative). Objectives The work presented in this thesis uses MRI data to quantitatively investigate structural differences between brains of patients with focal epilepsy and healthy controls using automated imaging preprocessing and analysis methods. Methods All patients studied in this thesis had electrophysiological evidence of focal epilepsy, and underwent routine clinical MRI prior to participation in this study. There were two datasets and both included a cohort of age-matched controls: (i) Patients with TLE and associated HS who later underwent selective amygdalahippocampectomy ... (continues)

Item Type:	Thesis (PhD)
Divisions:	Faculty of Health & Life Sciences
Depositing User:	Symplectic Admin
Date Deposited:	16 Aug 2018 08:37
Last Modified:	06 Feb 2025 07:30
DOI:	10.17638/03017303
Supervisors:	Keller, Simon S ORCID: 0000-0001-5247-9795
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3017303
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