Characterization of brain blood flow and the amplitude of low-frequency fluctuations in major depressive disorder: A multimodal meta-analysis.



Li, W, Chen, Z, Wu, M, Zhu, H, Gu, L, Zhao, Y, Kuang, W, Bi, F, Kemp, GJ ORCID: 0000-0002-8324-9666 and Gong, Q
(2017) Characterization of brain blood flow and the amplitude of low-frequency fluctuations in major depressive disorder: A multimodal meta-analysis. Journal of affective disorders, 210. 303 - 311.

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Abstract

Background In healthy subjects, there is an association between amplitude of low-frequency fluctuations (ALFF) and regional cerebral blood flow (rCBF). To date, no published meta-analysis has investigated changes in the regional ALFF in medication-free depressed patients. Methods In this study, we aimed to explore whether resting-state rCBF and ALFF changes co-occur in the depressed brain without the potential confound of medication. Using signed differential mapping (SDM), we conducted two meta-analyses, one of rCBF studies and one of ALFF studies, involving medication-free patients with major depressive disorder (MDD). In addition, we conducted a multimodal meta-analysis to identify brain regions that showed abnormalities in both rCBF and ALFF. Results A total of 16 studies were included in this series. We identified abnormalities in resting-state rCBF and ALFF in the left insula in medication-free MDD patients compared with healthy controls (HC). In addition, we observed altered resting-state rCBF in the limbic-subcortical-cortical circuit and altered ALFF in the default mode network (DMN) and some motor-related brain regions. Limitations The analysis techniques, patient characteristics and clinical variables of the included studies were heterogeneous. Conclusions The conjoint alterations in ALFF and rCBF in the left insula may represent core neuropathological changes in medication-free patients with MDD and merit further studying.

Item Type: Article
Uncontrolled Keywords: Major depressive disorder, Amplitude of low-frequency fluctuations, fMRI, Regional cerebral blood flow, Insula, Multimodal analysis
Depositing User: Symplectic Admin
Date Deposited: 19 Feb 2018 07:49
Last Modified: 21 Jun 2022 19:10
DOI: 10.1016/j.jad.2016.12.032
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3018214