TCRαβ<SUP>+</SUP>CD3<SUP>+</SUP>CD4<SUP>-</SUP>CD8<SUP>-</SUP> (double negative) T cells in autoimmunity

Brandt, D and Hedrich, CM ORCID: 0000-0002-1295-6179
(2018) TCRαβ<SUP>+</SUP>CD3<SUP>+</SUP>CD4<SUP>-</SUP>CD8<SUP>-</SUP> (double negative) T cells in autoimmunity. AUTOIMMUNITY REVIEWS, 17 (4). pp. 422-430.

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TCRαβ<sup>+</sup>CD3<sup>+</sup>CD4<sup>-</sup>CD8<sup>-</sup> "double negative" (DN) T cells comprise a small subset of mature peripheral T cells. The origin and function of DN T cells are somewhat unclear and discussed controversially. While DN T cells resemble a rare and heterogeneous T cell subpopulation in healthy individuals, numbers of TCRαβ<sup>+</sup> DN T cells are expanded in several inflammatory conditions, where they also exhibit distinct effector phenotypes and infiltrate inflamed tissues. Thus, DN T cells may be involved in systemic inflammation and tissue damage in autoimmune/inflammatory conditions, including SLE, Sjögren's syndrome, and psoriasis. Here, the current understanding of the origin and phenotype of DN T cells, and their role in the instruction of immune responses, autoimmunity and inflammation will be discussed in health and disease.

Item Type: Article
Uncontrolled Keywords: Double negative T cells, DN T cells, Effector T cells, SLE, Psoriasis, Inflammation
Depositing User: Symplectic Admin
Date Deposited: 23 Feb 2018 12:21
Last Modified: 13 Oct 2023 18:11
DOI: 10.1016/j.autrev.2018.02.001
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