Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance But Not VLDL Production in NAFLD

Shojaee-Moradie, F, Cuthbertson, DJ ORCID: 0000-0002-6128-0822, Barrett, M, Jackson, NC, Herring, R, Thomas, EL, Bell, J, Kemp, GJ ORCID: 0000-0002-8324-9666, Wright, J and Umpleby, AM (2016) Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance But Not VLDL Production in NAFLD. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 101 (11). pp. 4219-4228.

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Official URL: http://dx.doi.org/10.1210/jc.2016-2353

Abstract

<h4>Context</h4>Randomized controlled trials in nonalcoholic fatty liver disease (NAFLD) have shown that regular exercise, even without calorie restriction, reduces liver steatosis. A previous study has shown that 16 weeks of supervised exercise training in NAFLD did not affect total very low-density lipoprotein (VLDL) kinetics.<h4>Objective</h4>The objective of the study was to determine the effect of exercise training on intrahepatocellular fat (IHCL) and the kinetics of large triglyceride (TG)-rich VLDL<sub>1</sub> and smaller denser VLDL<sub>2</sub>, which has a lower TG content.<h4>Design</h4>This was a 16-week randomized controlled trial.<h4>Patients</h4>A total of 27 sedentary patients with NAFLD participated in the trial.<h4>Intervention</h4>The intervention was composed of supervised exercise with moderate-intensity aerobic exercise or conventional lifestyle advice (control).<h4>Main outcome</h4>VLDL<sub>1</sub> and VLDL<sub>2</sub>-TG and apolipoprotein B (apoB) kinetics were investigated using stable isotopes before and after the intervention.<h4>Results</h4>In the exercise group, maximal oxygen uptake increased by 31% ± 6% (mean ± SEM) and IHCL decreased from 19.6% (14.8%, 30.0%) to 8.9% (5.4%, 17.3%) (median [interquartile range]) with no significant change in maximal oxygen uptake or IHCL in the control group (change between groups, P < .001 and P = .02, respectively). Exercise training increased VLDL<sub>1</sub>-TG and apoB fractional catabolic rates, a measure of clearance, (change between groups, P = .02 and P = .01, respectively), and VLDL<sub>1</sub>-apoB production rate (change between groups, P = .006), with no change in VLDL<sub>1</sub>-TG production rate. Plasma TG did not change in either group.<h4>Conclusion</h4>An increased clearance of VLDL<sub>1</sub> may contribute to the significant decrease in liver fat after 16 weeks of exercise in NAFLD. A longer duration or higher-intensity exercise interventions may be needed to lower the plasma TG and VLDL production rate.

Item Type:	Article
Uncontrolled Keywords:	Liver, Humans, Triglycerides, Lipoproteins, VLDL, Apolipoproteins B, Exercise Therapy, Kinetics, Middle Aged, Male, Adiposity, Non-alcoholic Fatty Liver Disease, Sedentary Behavior, Outcome Assessment, Health Care
Depositing User:	Symplectic Admin
Date Deposited:	09 Mar 2018 09:25
Last Modified:	11 Sep 2023 20:50
DOI:	10.1210/jc.2016-2353
Open Access URL:	https://doi.org/10.1210/jc.2016-2353
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3018782