Increased Circulating Tissue Inhibitor of Metalloproteinase-2 Is Associated With Resistant Hypertension

Sabbatini, Andrea R, Barbaro, Natalia R, de Faria, Ana Paula, Modolo, Rodrigo, Ritter, Alessandra Mileni V, Pinho, Claudio, Amorim, Rivadavio Fernandes Batista, Fontana, Vanessa ORCID: 0000-0002-0146-9113 and Moreno, Heitor (2016) Increased Circulating Tissue Inhibitor of Metalloproteinase-2 Is Associated With Resistant Hypertension. JOURNAL OF CLINICAL HYPERTENSION, 18 (10). pp. 969-975.

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Abstract

Resistant hypertension (RH) is associated with organ damage and cardiovascular risk. Evidence suggests the involvement of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2) in hypertension and in cardiovascular remodeling. The aim of this study was to assess the levels of MMP-2 and TIMP-2 in RH and its relation with organ damage, including arterial stiffness and cardiac hypertrophy. MMP-2 and TIMP-2 levels were compared among 19 patients with normotension (NT), 116 with nonresistant hypertension (HTN) and 116 patients with resistant HTN (RH). MMP-2 levels showed no differences among NT, HTN, and RH groups, while TIMP-2 levels were higher in RH compared with HTN and NT groups (90.0 [76.1-107.3] vs 70.1 [57.7-88.3] vs 54.7 [40.9-58.1] ng/mL, P<.01), respectively. MMP-2/TIMP-2 ratio was reduced in the RH group compared with the HTN and NT groups (2.7 [1.9-3.4] vs 3.3 [2.6-4.2] vs 4.9 [4.5-5.3], P<.01), respectively. No associations were found between MMP-2 levels, TIMP-2, and MMP-2/TIMP-2 ratio with cardiac hypertrophy and arterial stiffness in the RH and HTN groups. Finally, in a regression analysis, reduced MMP-2/TIMP-2 ratio and increased TIMP-2 levels were independently associated with RH. The present findings provide evidence that TIMP-2 is associated with RH and might be a possible biomarker for screening RH patients.

Item Type:	Article
Uncontrolled Keywords:	Humans, Hypertension, Tissue Inhibitor of Metalloproteinase-2, Cross-Sectional Studies, Up-Regulation, Ventricular Remodeling, Aged, Middle Aged, Female, Male, Matrix Metalloproteinase 2, Vascular Stiffness
Depositing User:	Symplectic Admin
Date Deposited:	16 Mar 2018 11:13
Last Modified:	19 Jan 2023 06:38
DOI:	10.1111/jch.12865
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3019099