Sabbatini, Andrea R, Barbaro, Natalia R, de Faria, Ana Paula, Modolo, Rodrigo, Ritter, Alessandra Mileni V, Pinho, Claudio, Amorim, Rivadavio Fernandes Batista, Fontana, Vanessa ORCID: 0000-0002-0146-9113 and Moreno, Heitor
(2016)
Increased Circulating Tissue Inhibitor of Metalloproteinase-2 Is Associated With Resistant Hypertension.
JOURNAL OF CLINICAL HYPERTENSION, 18 (10).
pp. 969-975.
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Abstract
Resistant hypertension (RH) is associated with organ damage and cardiovascular risk. Evidence suggests the involvement of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2) in hypertension and in cardiovascular remodeling. The aim of this study was to assess the levels of MMP-2 and TIMP-2 in RH and its relation with organ damage, including arterial stiffness and cardiac hypertrophy. MMP-2 and TIMP-2 levels were compared among 19 patients with normotension (NT), 116 with nonresistant hypertension (HTN) and 116 patients with resistant HTN (RH). MMP-2 levels showed no differences among NT, HTN, and RH groups, while TIMP-2 levels were higher in RH compared with HTN and NT groups (90.0 [76.1-107.3] vs 70.1 [57.7-88.3] vs 54.7 [40.9-58.1] ng/mL, P<.01), respectively. MMP-2/TIMP-2 ratio was reduced in the RH group compared with the HTN and NT groups (2.7 [1.9-3.4] vs 3.3 [2.6-4.2] vs 4.9 [4.5-5.3], P<.01), respectively. No associations were found between MMP-2 levels, TIMP-2, and MMP-2/TIMP-2 ratio with cardiac hypertrophy and arterial stiffness in the RH and HTN groups. Finally, in a regression analysis, reduced MMP-2/TIMP-2 ratio and increased TIMP-2 levels were independently associated with RH. The present findings provide evidence that TIMP-2 is associated with RH and might be a possible biomarker for screening RH patients.
Item Type: | Article |
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Uncontrolled Keywords: | Humans, Hypertension, Tissue Inhibitor of Metalloproteinase-2, Cross-Sectional Studies, Up-Regulation, Ventricular Remodeling, Aged, Middle Aged, Female, Male, Matrix Metalloproteinase 2, Vascular Stiffness |
Depositing User: | Symplectic Admin |
Date Deposited: | 16 Mar 2018 11:13 |
Last Modified: | 19 Jan 2023 06:38 |
DOI: | 10.1111/jch.12865 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3019099 |