Hungerford, Daniel J
(2018)
Measuring the effect of rotavirus vaccination in primary and secondary care in Merseyside, UK.
PhD thesis, University of Liverpool.
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Abstract
Prior to the licensing and introduction of rotavirus vaccines in 2006, rotavirus was the most common cause of severe acute gastroenteritis (AGE) in children < 5 years of age, with the majority of disease burden occurring in children under two years of age. In the UK rotavirus was estimated to result in 80,000 general practice (GP) consultations in children < 5 years of age each year, together with 45% of hospitalisations and 20% of emergency department (ED) attendances for AGE. The UK introduced rotavirus vaccination into the routine childhood immunisation programme in July 2013. Whilst rotavirus vaccine impact on severe disease has been well described, uncovering vaccine impact on gastrointestinal (GI) disease outcomes across primary and secondary care is of public health importance; particularly understanding the extent of indirect effect or 'herd' protection. It is also important to ensure vaccine uptake and impact is equitable. As incidence of AGE is highest in the most socioeconomically deprived populations and vaccine uptake is often lower, measuring vaccine impact in relation to socioeconomic deprivation is critical. These themes were addressed through a series of inter-linked studies, for three years ... (continues)
| Item Type: | Thesis (PhD) |
|---|---|
| Divisions: | Faculty of Health and Life Sciences > Faculty of Health and Life Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 21 Aug 2018 09:44 |
| Last Modified: | 01 Sep 2024 18:43 |
| DOI: | 10.17638/03019338 |
| Supervisors: |
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| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3019338 |
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