Tayeb, FJ
(2018)
A study of genomic instability in Chronic Lymphocytic Leukaemia (CLL).
PhD thesis, University of Liverpool.
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Abstract
Chronic Lymphocytic Leukaemia (CLL) is a malignancy of mature B cells. The median age at diagnosis is 70-years old, mostly seen in Western Societies. Half of the patients show an indolent phenotype and watchful waiting is the recommended approach for their management. However, once treated, patients are heterogeneous in terms of response and relapse. Regarding prognosis, genetic testing, alongside current clinical staging, is important to guide treatment and prognosis. Deletion of the short arm of chromosome 17 (17p) is one of the worst prognostic markers for CLL and usually involves loss of heterozygosity (LOH) and mutations in the TP53 gene. P53 is one of the cell-cycle regulators that activates senescence, cell-cycle arrest, DNA repair or apoptosis as part of the DNA damage response (DDR). In some severe cases of CLL with inactivated P53, the DDR is affected in favour of CLL survival. However, there is a little knowledge regarding the relationship between TP53 and mutations affecting other DNA repair genes and whether these could lead to a synergistic effect. It was, therefore, the aim of this study to address this important question. Genomic DNA was extracted from blood CLL cells of 10 patients, all of ... (continues)
| Item Type: | Thesis (PhD) |
|---|---|
| Depositing User: | Symplectic Admin |
| Date Deposited: | 23 Aug 2018 14:00 |
| Last Modified: | 30 Sep 2024 02:15 |
| DOI: | 10.17638/03019754 |
| Supervisors: |
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| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3019754 |
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