Branched copolymer-stabilised nanoemulsions as new candidate oral drug delivery systems



Hobson, James ORCID: 0000-0003-2551-1774, Edwards, Stephanie ORCID: 0000-0002-4959-0158, Slater, Rebecca, Martin, Phillip, Owen, Andrew ORCID: 0000-0002-9819-7651 and Rannard, SP ORCID: 0000-0002-6946-1097
(2018) Branched copolymer-stabilised nanoemulsions as new candidate oral drug delivery systems. RSC Advances, 8 (23). pp. 12984-12991.

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Abstract

The delivery of drugs to the bloodstream <i>via</i> oral administration may suffer from a number of complications including poor dissolution, first pass metabolism and the active intervention of efflux transporters such as P-glycoproteins; drugs which are efflux substrates may cause considerable problems across many clinical conditions. Here we have employed a branch-polymer stabilised nanoemulsion strategy to create highly robust oil droplets (<i>e.g.</i> peanut oil, castor oil and soybean oil) containing different dissolved antiretroviral drugs used in the daily fight against HIV/AIDS. Although very limited difference in permeation through a Caco-2 gut epithelium model was seen for efavirenz, the permeation of the protease inhibitor lopinavir was considerably higher (approximately 10-fold) when applied to an epithelium monolayer in emulsion form than the control within an aqueous DMSO vehicle. The presented nanoemulsion approach may allow drug-specific permeation improvements for various drug substances.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 04 Apr 2018 09:49
Last Modified: 19 Jan 2023 06:36
DOI: 10.1039/c8ra01944d
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3019776