Branched copolymer-stabilised nanoemulsions as new candidate oral drug delivery systems

Hobson, James ORCID: 0000-0003-2551-1774, Edwards, Stephanie ORCID: 0000-0002-4959-0158, Slater, Rebecca, Martin, Phillip, Owen, Andrew ORCID: 0000-0002-9819-7651 and Rannard, SP ORCID: 0000-0002-6946-1097 (2018) Branched copolymer-stabilised nanoemulsions as new candidate oral drug delivery systems. RSC Advances, 8 (23). pp. 12984-12991.

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Abstract

The delivery of drugs to the bloodstream <i>via</i> oral administration may suffer from a number of complications including poor dissolution, first pass metabolism and the active intervention of efflux transporters such as P-glycoproteins; drugs which are efflux substrates may cause considerable problems across many clinical conditions. Here we have employed a branch-polymer stabilised nanoemulsion strategy to create highly robust oil droplets (<i>e.g.</i> peanut oil, castor oil and soybean oil) containing different dissolved antiretroviral drugs used in the daily fight against HIV/AIDS. Although very limited difference in permeation through a Caco-2 gut epithelium model was seen for efavirenz, the permeation of the protease inhibitor lopinavir was considerably higher (approximately 10-fold) when applied to an epithelium monolayer in emulsion form than the control within an aqueous DMSO vehicle. The presented nanoemulsion approach may allow drug-specific permeation improvements for various drug substances.

Item Type:	Article
Uncontrolled Keywords:	HIV/AIDS, 5.1 Pharmaceuticals, 5 Development of treatments and therapeutic interventions
Depositing User:	Symplectic Admin
Date Deposited:	04 Apr 2018 09:49
Last Modified:	14 Mar 2024 19:10
DOI:	10.1039/c8ra01944d
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3019776