Takeshita, LYC
(2018)
The effect of immunogenetic variability on human health : bioinformatics investigations from different perspectives.
PhD thesis, University of Liverpool.
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Abstract
The high level of diversity exhibited by genes coding for molecules involved in the immune system are critically involved with several aspects of human health. The ability of the immune system to recognize foreign pathogens or abnormal cells, while tolerating itself is achieved through a balance of various components and receptors in the immune system. Individual genotypes of immune genes such as HLA and KIR fine-tune this balance. Variability in those genes lead to diversity in the response to foreign molecules, and can also lead to intolerance to self-molecules in the form of autoimmune responses. Several past studies have found HLA and KIR polymorphisms to be associated with susceptibility or protection to a range of diseases and hypersensitivity to drugs. HLA has also a major role in transplantation, where transplanted tissues need to be as similar as possible to avoid rejection. The work described in this thesis contributes towards the knowledge of immunogenetic implications in associations with diseases, transplantation and adverse reactions to drugs using different bioinformatics approaches. First, it provides bioinformatics resources for a better understanding of the impact of immunogenetic diversity ... (continues)
| Item Type: | Thesis (PhD) |
|---|---|
| Divisions: | Faculty of Health and Life Sciences > Faculty of Health and Life Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 16 Aug 2018 14:27 |
| Last Modified: | 08 Feb 2025 01:40 |
| DOI: | 10.17638/03020019 |
| Supervisors: |
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| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3020019 |
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