Horizontal antimicrobial resistance transfer drives epidemics of multiple Shigella species



Baker, KS ORCID: 0000-0001-5850-1949, Dallman, Timothy, Field, Nigel, Childs, Tristan, Mitchell, Holly, Day, Martin, Weill, Francois-Xavier, Lefevre, Sophie, Tourdjman, Mathieu, Hughes, Gwenda
et al (show 2 more authors) (2018) Horizontal antimicrobial resistance transfer drives epidemics of multiple Shigella species. Nature Communications, 9.

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Abstract

Horizontal gene transfer has played a role in developing the global public health crisis of antimicrobial resistance (AMR). However, the dynamics of AMR transfer through bacterial populations and its direct impact on human disease is poorly elucidated. Here, we study parallel epidemic emergences of multiple Shigella species, a priority AMR organism, in men who have sex with men to gain insight into AMR emergence and spread. Using genomic epidemiology, we show that repeated horizontal transfer of a single AMR plasmid among Shigella enhanced existing and facilitated new epidemics. These epidemic patterns contrasted with slighter, slower increases in disease caused by organisms with vertically inherited (chromosomally encoded) AMR. This demonstrates that horizontal transfer of AMR directly affects epidemiological outcomes of globally important AMR pathogens and highlights the need for integration of genomic analyses into all areas of AMR research, surveillance and management.

Item Type: Article
Uncontrolled Keywords: antimicrobial resistance, bacterial infection, epidemiology, molecular medicine
Depositing User: Symplectic Admin
Date Deposited: 16 Apr 2018 06:37
Last Modified: 01 Sep 2022 18:12
DOI: 10.1038/s41467-018-03949-8
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3020165