The role of ketogenic diets in the therapeutic management of adult and paediatric gliomas: a systematic review.

Martin-McGill, Kirsty J ORCID: 0000-0002-5138-2497, Srikandarajah, Nisaharan, Marson, Anthony G ORCID: 0000-0002-6861-8806, Tudur Smith, Catrin ORCID: 0000-0003-3051-1445 and Jenkinson, Michael D ORCID: 0000-0003-4587-2139 (2018) The role of ketogenic diets in the therapeutic management of adult and paediatric gliomas: a systematic review. CNS oncology, 7 (2). CNS17-.

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Abstract

<h4>Aim</h4>We performed a systematic review of the evidence for effectiveness and acceptability of different ketogenic diets (KDs) in the therapeutic management of gliomas.<h4>Methods</h4>The search strategy included searches of seven electronic databases. Data extraction and quality assessment were undertaken independently by two authors.<h4>Results</h4>No randomized clinical trials were identified. Six studies (n = 39) met the eligibility criteria for this review - all were case series or reports and therefore at high risk of bias. All studies reported overall or progression-free survival; however the effectiveness of KD interventions could not be established. Dietary acceptability was not reported.<h4>Conclusion</h4>The effectiveness and acceptability of KDs in the management of gliomas is unknown and high quality randomized controlled trials are needed.

Item Type:	Article
Uncontrolled Keywords:	Animals, Humans, Glioma, Brain Neoplasms, Adult, Child, Disease Management, Diet, Ketogenic
Depositing User:	Symplectic Admin
Date Deposited:	17 Apr 2018 06:36
Last Modified:	01 Feb 2024 19:01
DOI:	10.2217/cns-2017-0030
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3020229