Impact of cell types and culture methods on the functionality of <i>in vitro</i> liver systems - A review of cell systems for hepatotoxicity assessment

Kyffin, Jonathan A, Sharma, Parveen ORCID: 0000-0002-5211-7177, Leedale, Joseph ORCID: 0000-0001-9010-4126, Colley, Helen E, Murdoch, Craig, Mistry, Pratibha and Webb, Steven D (2018) Impact of cell types and culture methods on the functionality of <i>in vitro</i> liver systems - A review of cell systems for hepatotoxicity assessment. TOXICOLOGY IN VITRO, 48. pp. 262-275. ISSN 0887-2333, 1879-3177

Text Kyfinn et al 2018_revised.pdf - Author Accepted Manuscript Download (1MB)

Abstract

Xenobiotic safety assessment is an area that impacts a multitude of different industry sectors such as medicinal drugs, agrochemicals, industrial chemicals, cosmetics and environmental contaminants. As such there are a number of well-developed in vitro, in vivo and in silico approaches to evaluate their properties and potential impact on the environment and to humans. Additionally, there is the continual investment in multidisciplinary scientists to explore non-animal surrogate technologies to predict specific toxicological outcomes and to improve our understanding of the biological processes regarding the toxic potential of xenobiotics. Here we provide a concise, critical evaluation of a number of in vitro systems utilised to assess the hepatotoxic potential of xenobiotics.

Item Type:	Article
Uncontrolled Keywords:	In vitro toxicology, Xenobiotic safety, Hepatotoxicity, 3D cell culture models, Liver spheroids
Depositing User:	Symplectic Admin
Date Deposited:	23 Apr 2018 07:08
Last Modified:	06 Dec 2024 23:30
DOI:	10.1016/j.tiv.2018.01.023
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3020420