Clinical Pharmacogenetics Implementation Consortium Guideline for <i>HLA</i> Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update


Phillips, Elizabeth J, Sukasem, Chonlaphat, Whirl-Carrillo, Michelle, Mueller, Daniel J, Dunnenberger, Henry M, Chantratita, Wasun, Goldspiel, Barry, Chen, Yuan-Tsong, Carleton, Bruce C, George, Alfred L et al (show 4 more authors) (2018) Clinical Pharmacogenetics Implementation Consortium Guideline for <i>HLA</i> Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update. CLINICAL PHARMACOLOGY & THERAPEUTICS, 103 (4). pp. 574-581.

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Abstract

The variant allele HLA-B*15:02 is strongly associated with greater risk of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients treated with carbamazepine or oxcarbazepine. The variant allele HLA-A*31:01 is associated with greater risk of maculopapular exanthema, drug reaction with eosinophilia and systemic symptoms, and SJS/TEN in patients treated with carbamazepine. We summarize evidence from the published literature supporting these associations and provide recommendations for carbamazepine and oxcarbazepine use based on HLA genotypes.

Item Type: Article
Uncontrolled Keywords: Humans, Carbamazepine, Anticonvulsants, HLA-B Antigens, Pharmacogenetics, Drug-Related Side Effects and Adverse Reactions, Oxcarbazepine
Depositing User: Symplectic Admin
Date Deposited: 25 Apr 2018 06:33
Last Modified: 13 Oct 2023 13:04
DOI: 10.1002/cpt.1004
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3020562
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