A web resource for mining HLA associations with adverse drug reactions: HLA-ADR.



Ghattaoraya, Gurpreet S ORCID: 0000-0003-4809-7342, Dundar, Yenal ORCID: 0000-0002-9847-1622, González-Galarza, Faviel F, Maia, Maria Helena Thomaz, Santos, Eduardo José Melo, da Silva, Andréa Luciana Soares, McCabe, Antony ORCID: 0000-0003-3089-3674, Middleton, Derek, Alfirevic, Ana ORCID: 0000-0002-2801-9817, Dickson, Rumona ORCID: 0000-0003-1416-0913
et al (show 1 more authors) (2016) A web resource for mining HLA associations with adverse drug reactions: HLA-ADR. Database : the journal of biological databases and curation, 2016.

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Abstract

Human leukocyte antigens (HLA) are an important family of genes involved in the immune system. Their primary function is to allow the host immune system to be able to distinguish between self and non-self peptides-e.g. derived from invading pathogens. However, these genes have also been implicated in immune-mediated adverse drug reactions (ADRs), presenting a problem to patients, clinicians and pharmaceutical companies. We have previously developed the Allele Frequency Net Database (AFND) that captures the allelic and haplotype frequencies for these HLA genes across many healthy populations from around the world. Here, we report the development and release of the HLA-ADR database that captures data from publications where HLA alleles and haplotypes have been associated with ADRs (e.g. Stevens-Johnson Syndrome/toxic epidermal necrolysis and drug-induced liver injury). HLA-ADR was created by using data obtained through systematic review of the literature and semi-automated literature mining. The database also draws on data already present in AFND allowing users to compare and analyze allele frequencies in both ADR patients and healthy populations. The HLA-ADR database provides clinicians and researchers with a centralized resource from which to investigate immune-mediated ADRs.Database URL: http://www.allelefrequencies.net/hla-adr/.

Item Type: Article
Uncontrolled Keywords: Humans, HLA Antigens, Database Management Systems, User-Computer Interface, Databases, Factual, Drug-Related Side Effects and Adverse Reactions
Depositing User: Symplectic Admin
Date Deposited: 30 Apr 2018 08:24
Last Modified: 25 Jan 2022 18:16
DOI: 10.1093/database/baw069
URI: https://livrepository.liverpool.ac.uk/id/eprint/3020677