The long-term outcomes of epilepsy surgery

Mohan, Midhun, Keller, Simon ORCID: 0000-0001-5247-9795, Nicolson, Andrew, Biswas, Shubhabrata, Smith, David, Farah, Jibril Osman, Eldridge, Paul and Wieshmann, Udo (2018) The long-term outcomes of epilepsy surgery PLOS ONE, 13 (5). e0196274-. ISSN 1932-6203, 1932-6203

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Abstract

Objective Despite modern anti-epileptic drug treatment, approximately 30% of epilepsies remain medically refractory and for these patients, epilepsy surgery may be a treatment option. There have been numerous studies demonstrating good outcome of epilepsy surgery in the short to median term however, there are a limited number of studies looking at the long-term outcomes. The aim of this study was to ascertain the long-term outcome of resective epilepsy surgery in a large neurosurgery hospital in the U.K.Methods This a retrospective analysis of prospectively collected data. We used the 2001 International League Against Epilepsy (ILAE) classification system to classify seizure freedom and Kaplan-Meier survival analysis to estimate the probability of seizure freedom. Results We included 284 patients who underwent epilepsy surgery (178 anterior temporal lobe resections, 37 selective amygdalohippocampectomies, 33 temporal lesionectomies, 36 extratemporal lesionectomies), and had a prospective median follow-up of 5 years (range 1–27). Kaplan-Meier estimates showed that 47% (95% CI 40–58) remained seizure free (apart from simple partial seizures) at 5 years and 38% (95% CI 31–45) at 10 years after surgery. 74% (95% CI 69–80) had a greater than 50% seizure reduction at 5 years and 70% (95% CI 64–77) at 10 years. Patients who had an amygdalohippocampectomy were more likely to have seizure recurrence than patients who had an anterior temporal lobe resection (p = 0.006) and temporal lesionectomy (p = 0.029). There was no significant difference between extra temporal and temporal lesionectomies. Hippocampal sclerosis was associated with a good outcome but declined in relative frequency over the years. Conclusion The vast majority of patients who were not seizure free experienced at least a substantial and long-lasting reduction in seizure frequency. A positive long-term outcome after epilepsy surgery is possible for many patients and especially those with hippocampal sclerosis or those who had anterior temporal lobe resections.

Item Type:	Article
Uncontrolled Keywords:	Amygdala, Hippocampus, Temporal Lobe, Humans, Epilepsy, Epilepsy, Temporal Lobe, Treatment Outcome, Neurosurgical Procedures, Prospective Studies, Drug Resistance, Time Factors, Adult, Female, Male, Kaplan-Meier Estimate, United Kingdom
Depositing User:	Symplectic Admin
Date Deposited:	18 May 2018 15:19
Last Modified:	16 Jun 2026 14:28
DOI:	10.1371/journal.pone.0196274
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3021476
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