Waters, AM
(2018)
A core outcome set for clinical trials in oropharyngeal cancer.
PhD thesis, University of Liverpool.
Text
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Abstract
The impact of randomized controlled trials is frequently diminished by disparate outcome reporting, precluding the comparison of results between trials or synthesis of data in meta-analyses. This is particularly problematic in lower incidence conditions such as oropharyngeal squamous cell carcinoma (OPSCC), where the need to synthesise data from competing trials is greater. Minimum outcome reporting standards, known as Core Outcome Sets (COS) have been shown to increase the consistency of outcome reporting between trials of comparable interventions, thus facilitating the comparison or synthesis of trial data. The objective of the work in this thesis was to identify outcomes of importance to patients, carers and healthcare professionals and define a COS for OPSCC. The methods used comprised a systematic review of OPSCC RCTs to identify the outcomes reported and establish whether there was outcomes heterogeneity as suggested by other studies; semi-structured qualitative interviews with patients and carers to establish their outcomes of importance; a Delphi Study of patients, carers and healthcare professionals, to reach consensus on the outcomes that should be included in a COS for OPSCC. The systematic review ... (continues)
Item Type: | Thesis (PhD) |
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Divisions: | Faculty of Health and Life Sciences > Faculty of Health and Life Sciences |
Depositing User: | Symplectic Admin |
Date Deposited: | 15 Aug 2018 08:29 |
Last Modified: | 24 Aug 2024 09:48 |
DOI: | 10.17638/03022643 |
Supervisors: |
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URI: | https://livrepository.liverpool.ac.uk/id/eprint/3022643 |