Gamma-delta T-cell lymphoma of skin, eye and brain presenting with visual loss.



Jones, Nicholas ORCID: 0000-0002-4299-3624, Gibb, Adam, Irion, Luciane and Coupland, Sarah ORCID: 0000-0002-1464-2069
(2017) Gamma-delta T-cell lymphoma of skin, eye and brain presenting with visual loss. BMJ case reports, 2017.

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Abstract

A young man presented with rapid, predominantly right-sided visual loss with a background of multifocal skin lesions. Visual acuity was right hand movements, left 6/5 Snellen, deteriorating to 6/38. He showed panuveitis with bilateral multifocal retinal infiltrates and retinal vasculitis. Multifocal brain lesions were identified. Biopsy of both skin and vitreous showed atypical lymphocytes, and immunohistochemistry confirmed T-cell lymphoma of gamma-delta subtype. Management with the CODOX-M/IVAC polychemotherapy regimen achieved rapid response including resolution of intraocular changes and substantial improvement of visual acuity to right 6/7.5, left 6/6. However, he relapsed before planned stem cell transplantation. Salvage with the gemcitabine/dexamethasone/cisplatin regimen, although temporarily effective, was followed by further relapse including widespread brain involvement, and he succumbed 10 months after presentation.

Item Type: Article
Uncontrolled Keywords: Brain, Skin, Humans, Lymphoma, T-Cell, Neoplasm Recurrence, Local, Vision, Low, Cyclophosphamide, Vincristine, Methotrexate, Doxorubicin, Antineoplastic Combined Chemotherapy Protocols, Salvage Therapy, Fatal Outcome, Male, Young Adult
Depositing User: Symplectic Admin
Date Deposited: 04 Nov 2019 09:58
Last Modified: 21 Jun 2021 20:10
DOI: 10.1136/bcr-2017-219946
URI: https://livrepository.liverpool.ac.uk/id/eprint/3023095