Analysis of shared heritability in common disorders of the brain

Anttila, Verneri, Bulik-Sullivan, Brendan, Finucane, Hilary K, Walters, Raymond K, Bras, Jose, Duncan, Laramie, Escott-Price, Valentina, Falcone, Guido J, Gormley, Padhraig, Malik, Rainer
et al (show 561 more authors) (2018) Analysis of shared heritability in common disorders of the brain. SCIENCE, 360 (6395). 1313-+.

This is the latest version of this item.

[img] Text
aap8757_MainText.docx - Author Accepted Manuscript

Download (304kB)
[img] Text
aap8757_MainText.docx - Author Accepted Manuscript

Download (379kB)


Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.

Item Type: Article
Uncontrolled Keywords: Brainstorm Consortium, Humans, Brain Diseases, Risk Factors, Mental Disorders, Quantitative Trait, Heritable, Phenotype, Genetic Variation, Genome-Wide Association Study
Depositing User: Symplectic Admin
Date Deposited: 07 Aug 2018 06:18
Last Modified: 19 Jan 2023 01:29
DOI: 10.1126/science.aap8757
Related URLs:

Available Versions of this Item