Comparison between SELEX and single-step selection for the identification of bivalent aptamers for thrombin

Wilson, Robert, Bourne, Christian, Chaudhuri, Roy, Gregory, Richard, Kenny, John and Cossins, Andrew ORCID: 0000-0002-0813-5212 (2021) Comparison between SELEX and single-step selection for the identification of bivalent aptamers for thrombin. Angewandte Chemie International Edition, 9 (6). e100572-. ISSN 1433-7851, 1521-3773 (Submitted)

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Abstract

The identification of bivalent aptamers for thrombin by SELEX and single-step selection are compared using next generation (massively parallel) sequencing and motif finding informatics. Results show that similar aptamers are identified by both methods.

Item Type:	Article
Additional Information:	35 pages. Date: 2014 (submitted)
Uncontrolled Keywords:	31 Biological Sciences, 3102 Bioinformatics and Computational Biology, Genetics, Biotechnology, Aptamers, Nucleotide, Base Sequence, Catalytic Domain, Computational Biology, High-Throughput Nucleotide Sequencing, Humans, Models, Molecular, Nucleotide Motifs, SELEX Aptamer Technique, Sequence Analysis, DNA, Thrombin
Subjects:	?? QP ??
Divisions:	Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	17 Aug 2018 14:24
Last Modified:	21 Nov 2024 20:29
DOI:	10.1371/journal.pone.0100572
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3025151

Available Versions of this Item

• Comparison between SELEX and single-step selection for the identification of bivalent aptamers for thrombin. (deposited 06 Jan 2014 10:14)
  • Comparison between SELEX and single-step selection for the identification of bivalent aptamers for thrombin. (deposited 17 Aug 2018 14:24) [Currently Displayed]