Developments in Cardiovascular Proteomics

A Noronha, Melissa and Linden, Christopher (2016) Developments in Cardiovascular Proteomics. Journal of Proteomics & Bioinformatics, 09 (05). ISSN 0974-276X, 0974-276X

Text Noronha et al final version.pdf - Published version Download (661kB)

Abstract

Cardiovascular diseases (CVD) are the leading cause of mortality and morbidity worldwide. These diseases can occur rapidly as seen in acute myocardial infarction or develop over a number of years as seen in chronic heart failure. The use of a number of drugs for chronic conditions in our aging population is compounding existing rates of CVDs due to cardiotoxicity. Recent advances in proteomics coupled with innovative separation and isolation techniques of subproteomes have vastly improved our knowledge of the cardiac proteome. Mass spectrometry imaging (MSI) is further providing information on spatial distribution of proteins and drugs. Here, we evaluate current advances in separation and detection of proteins, drugs and active metabolites being used to gain insights into mechanisms and diagnostic markers. Taken together these innovative techniques provide the necessary tools to investigate a system biology approach into cardiac disease and toxicity.

Item Type:	Article
Uncontrolled Keywords:	3401 Analytical Chemistry, 32 Biomedical and Clinical Sciences, 34 Chemical Sciences, Heart Disease, Aging, Cardiovascular, Heart Disease - Coronary Heart Disease, Cardiovascular, 3 Good Health and Well Being
Depositing User:	Symplectic Admin
Date Deposited:	17 Aug 2018 14:24
Last Modified:	16 Aug 2025 05:25
DOI:	10.4172/jpb.1000400
Related Websites:	Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3025171

Available Versions of this Item

• Developments in Cardiovascular Proteomics. (deposited 17 May 2016 15:29)
  • Developments in Cardiovascular Proteomics. (deposited 17 Aug 2018 14:24) [Currently Displayed]