The effect of outdoor air pollution on the risk of hospitalisation for bronchiolitis in infants: a systematic review

King, Charlotte ORCID: 0000-0002-7887-3640, Kirkham, Jamie ORCID: 0000-0003-2579-9325, Hawcutt, Daniel ORCID: 0000-0002-8120-6507 and Sinha, Ian (2018) The effect of outdoor air pollution on the risk of hospitalisation for bronchiolitis in infants: a systematic review. PEERJ, 6 (8). e5352-.

Text A SYSTEMATIC REVIEW OF THE EFFECT OF OUTDOOR AIR POLLUTION ON THE RISK OF HOSPITALISATION FOR BRONCHIOLITIS IN INFANTS PeerJ final submission.docx - Author Accepted Manuscript Download (196kB)

Abstract

<h4>Objective</h4>To systematically review the evidence around the effect of ambient levels of particulate and gaseous pollutants, and the risk of hospitalisation with bronchiolitis for infants under two years of age.<h4>Design</h4>Systematic review of observational epidemiological studies including cohort, time series, case crossover and case control study designs.<h4>Data sources</h4>Medline, Scopus, and Web of Science searched to November 2017 with no language restrictions.<h4>Eligibility criteria</h4>Studies investigating impact of air pollution levels on particulate pollutants (diameter <2.5 μm (PM2.5) or <10 μm (PM10) and gaseous pollutants (nitrogen dioxide (NO₂), sulphur dioxide (SO₂), carbon monoxide (CO), ozone (O₃)) on hospital admission for bronchiolitis.<h4>Main outcome measure</h4>Risk of hospitalisation from bronchiolitis.<h4>Results</h4>Eight studies were eligible for review. Long term exposure to PM2.5 may be associated with increased risk of hospitalisation for bronchiolitis. SO₂ may also be associated with hospitalisation, but results for other pollutants are inconsistent between studies. In three of the five studies that showed a positive association between air pollutants and hospitalisation, measured concentrations were below World Health Organization (WHO) recommended levels.<h4>Conclusions</h4>Certain particulate and gaseous pollutants may have a clinically relevant effect on hospital admissions for bronchiolitis in children below age two years old. Large cohort or time series studies are needed to examine this possible association.<h4>Protocol</h4>The protocol can be found at PROSPERO (CRD42017080643).

Item Type:	Article
Uncontrolled Keywords:	Bronchiolitis, Air pollution, Hospitalisation, Systematic review
Depositing User:	Symplectic Admin
Date Deposited:	22 Aug 2018 14:53
Last Modified:	19 Jan 2023 01:26
DOI:	10.7717/peerj.5352
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3025418