An assessment of the use of routinely recorded data in the UK in a randomised controlled trial


Powell, Graham Arnold (2018) An assessment of the use of routinely recorded data in the UK in a randomised controlled trial. PhD thesis, University of.

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Abstract

Introduction and Objectives: Routinely recorded clinical data held in administrative healthcare databases have demonstrated utility in Randomised Controlled Trials (RCTs), such as informing recruitment feasibility assessments, assisting with recruitment and measuring certain study outcomes. Furthermore, routinely recorded non-clinical data, such as data regarding employment and taxation have the potential to inform the measurement of outcomes including health economic analyses. However, limitations with accuracy, access and feasibility have been identified. This research systematically reviewed the use of routinely recorded data in the UK in RCTs and agreement of routinely recorded data compared to data collected using standard prospective research methods. Subsequently, the accessibility, quality, agreement and feasibility of using routinely recorded data compared to data collected using standard prospective methods: in a UK RCT assessing antiepileptic drug treatments for individuals newly diagnosed with epilepsy were assessed. Methods A systematic review was undertaken to assess the use of routinely recorded data in the UK in RCTs and to compare agreement between routinely recorded data and data collected ... (continues)

Item Type: Thesis (PhD)
Divisions: Faculty of Health and Life Sciences > Faculty of Health and Life Sciences
Depositing User: Symplectic Admin
Date Deposited: 30 Nov 2018 15:31
Last Modified: 08 Feb 2025 01:46
DOI: 10.17638/03026084
Supervisors:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3026084
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